NONLINEAR MODELS FORIN VITROKILL KINETICS OF ANTIBIOTICS

摘要

In this study, we developed nonlinear regression models to analyze the data generated from anin vitrocontinuous culture system to assess the kinetics of metronidazole and trovafloxacin in inhibiting the growth ofBacteroides fragilis. The model includes parameters describing the initial shock effect of an antibiotic pulse, the overall antibiotic wash-out rate from the system, and the long-term toxicity of the antibiotic in the environment after one pulse and before the next pulse.