It is commonly believed that a high recombination rate such as that in a pseudoautosomal region (PAR) greatly increases the mutation rate because a 170-fold increase was estimated for the mouse PAR region. However, sequencing PAR and non-PAR introns of the Fxy gene in four Mus taxa, we found an increase of only twofold to fivefold. Furthermore, analyses of sequence data from human and orangutan PAR and X-linked regions and from autosomal regions showed a weak effect of recombination on mutation rate (a slope of less than 0.2 per cM/Mb), although a much stronger effect on GC content (1 to 2 per cM/Mb). Because typical recombination rates in mammals are much lower than those in PARs, the mutagenicity of recombination is weak or, at best, moderate, although its effect on GC is much stronger. In addition, contrary to a previous study, we found no Fxy duplicate in Mus spretus.
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机译：人们普遍认为，高重组率（例如假常染色体区域 （PAR）中的重组率会大大增加突变率，因为估计小鼠 PAR 区域增加了 170 倍。然而，对四个Mus分类群中Fxy基因的PAR和非PAR内含子进行测序，我们发现仅增加了两倍到五倍。此外，对来自人类和猩猩PAR和X连锁区域以及常染色体区域的序列数据的分析显示，重组对突变率的影响较弱（斜率小于0.2%/cM/Mb），但对GC含量的影响要强得多（1%至2%/cM/Mb）。由于哺乳动物的典型重组率远低于PARs，因此重组的致突变性较弱，或者充其量是中等的，尽管它对GC%的影响要强得多。此外，与之前的研究相反，我们在Mus spretus中没有发现Fxy重复。
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