Variable association of DNA polymerase with the cytoskeletal fractions of resting and dividing cells

摘要

A DNA polymerase activity associated with the detergent insoluble cytoskeletal fraction has been identified in dividing and non-dividing rat hepatocytes and a hepatoma (the Zajdela Ascitic Hepatoma). About 35 of the enzyme is found associated with the cytoskeletal fraction of non-dividing cells as compared to about 3–6 of the enzyme in dividing cells even though the dividing cells contain larger amounts of the extranuclear enzyme. The properties of the enzyme are similar to those of DNA polymerase-v. It is suggested that the association of the enzyme with the cytoskeletal fraction has functional significanc