Serum levels of 25-hydroxyvitamin D are associated with cognitive impairment in type 2 diabetic adults

摘要

Hypovitaminosis D is highly prevalent in type 2 diabetes. The aim of this study is to determine the serum levels of 25-hydroxy vitamin D 25(OH)D in type 2 diabetic patients with and without mild cognitive impairment (MCI), and examine the relationship of 25(OH)D and MCI with other clinical factors. One hundred and sixty-five diabetic patients were enrolled in this study. Among whom, 95 patients were considered as MCI Montreal Cognitive Assessment score (MoCA) 26). Subjects were assessed clinically. Diabetic patients with MCI had a longer duration of DM, fewer years of education, elevated fasting blood glucose (FBG), resistant index (RI) of carotid, and lower levels of 25(OH)D {17.35 (13.02-25.92) vs 28.00 (19.67-34.30) ng/ml, P< 0.001}. The MoCA score was positively correlated with log1025(OH)D, education year, and inversely correlated with duration of DM, history of hypertension, intima-media thickness (IMT), FBG, max-RI, and min-RI. Logi025(OH)D was positively correlated with MoCA score, and inversely correlated with IMT, in multivariate regression analysis adjusted for age, sex, and education year, 25(OH)D (?= 0.210, P = 0.003), history of hypertension (0 = -0.191, P = 0.007), IMT (fi = -0.194, P = 0.007), and FBG (0 = -0.157, P = 0.026) independently predicted MoCA score. In conclusion, our results suggest that levels of serum 25(OH)D are inversely associated with the cognitive impairment in diabetic patients. Vitamin D may be a potential protective factor for cognitive impairment in patients with type 2 diabetes.