17 beta-Estradiol in the systemic circulation derives mainly from the parietal cells in cholestatic female rats

摘要

Purpose Estrogenic symptoms of liver disease patients including biliary tract disorder with high frequency is observed in clinical cases. However, the origin of 17 beta-estradiol which is abundant enough to cause symptoms remains uncertain. In male rats, it has been reported that the parietal cells which have an abundance of aromatase-synthesized 17 beta-estradiol, and a part of 17 beta-estradiol secreted into the portal vein, may flow into the systemic circulation under a pathophysiological condition of the liver including bile duct ligation (BDL). The aim of this study is to reveal the origin of 17 beta-estradiol increment in female rats and to investigate the effect of BDL on the ovary during the estrus cycle.