A Monoclonal Anti‐keratin Antibody Reactive with Amyloid Deposit of Primary Cutaneous Amyloidosis

摘要

AbstractSpecimens from cutaneous amyloidoses (lichen amyloidosis and macular amyloidosis) were stained immunohistochemically with monoclonal anti‐keratin antibodies. One monoclonal antibody raised against hair keratin (HKN‐6) reacted with the amyloids of both primary amyloidoses. Another monoclonal antibody, HKN‐2, did not decorate the amyloid deposit. HKN‐6 did not stain the interfollicular epidermis, but HKN‐2 did. The possible explanations of these findings are 1) amyloid deposits contain keratin protein modulated to react with HKN‐6; 2) amyloid deposits contain a protein unrelated to keratin protein, but reacti