Is the DNA synthesis of pancreatic islets influenced by the MHC and/or the genetic background?

摘要

Neonatal pancreatic rat islets were used to investigate the effect of MHC haplotype RT1uon islet replication measured by incorporation of3H-thymidine and autoradiography. The special interest in RT1uresulted from the fact that BB rats, which develop an insulin-dependent diabetes, belong to the RT1uhaplotype. Thus, the RT1u, when influencing the replication, may be involved in the development of the B-cell deficiency observed in diabetic rats.