Response to letter to the Editor regarding manuscript published In Inhalation Toxicology, vol. 20, Issue 10: Thrombotic markers In metabolic syndrome subjects exposd to dlesel exhaust

摘要

We thank the correspondents for their interest in our work. As our study was not intended to address the role of immunology potentially contributing to thrombosis related to diesel exhaust (DE) and we did not include allergen exposure, we did not reference the suggested literature. With this opportunity, however, we note that the literature to date is sparse with regards to direct laboratory investigation of a role for allergens in DE-mediated thrombosis. Other explanations for such phenomena, perhaps equally likely to those proposed, include particle-related epithelial damage (either facilitating or taking advantage of predisposed access of allergen to sub-epithelial dendritic-and other-cells (Knight, 2002) or allergen-related oxidative stress (Dworski et al, 1999) that (independent of formal hypersensitivity but coincident with DE-related