An efficient microwave-assisted synthesis of thieno2,3-bquinolines under solvent-free conditions

摘要

A novel and efficient method for the synthesis of substituted thieno2,3-bquinolines has been developed. A simple one-pot reaction of 3-formyl-2-mercaptoquinolines 2a-l with 1 -chloroacetone, 2-chloroacetamide, ethyl chloroacetate and 2-chloro-1 -phenylethanone in presence of catalytic amount of potassium carbonate under microwave irradiation and solvent-free conditions gave thieno2,3-bquinolin-2-ylethanone derivatives 3a-e, thieno2,3-bquinoline-2-carboxamide derivatives 4a-e, ethyl thieno2,3-b>quinoline-2-carboxylate 5a-e and phenyl(thieno2,3-bquinolin-2-yl)methanone derivatives 6a-e compounds respectively. The structures of all the newly synthesised compounds were elucidated on the basis of elemental analysis, IR, ' H NMR and mass spectral data.