Asymptotic distributions of polylocus test statistics

摘要

AbstractPolylocus linkage analysis methods are modified two‐point analyses which aim to approach the information gain of multilocus analysis. Terwilliger and Ott (1992)Am J Hum Genet51:A202, (1993)Genet Epidemiol10:477–482 put forth two such methods. This paper presents asymptotic approximations to the null distribution of the likelihood ratio statistics for these two methods, correcting earlier reports Terwilliger and Ott (1993)Genet Epidemiol10:477–482; Schaid and Elston (1994)Genet Epidemiol11:1–17. The performance of the approximations is then assessed for finite samples of fully informative meioses. © 1995 Wiley