Highhyphen;Performance Liquid Chromatographic Assay for the Simultaneous Measurement of Trimethoprim and Sulfamethoxazole in Plasma or Urine

摘要

Procedures for the simultaneous determination of trimethoprim (TMP) and sulfamethoxazole (SMX) in plasma or urine are reported. The drugs are extracted from plasma or urine by a single solid-phase extraction and quantitated by high-performance liquid chromatography. Both drugs are analyzed in the same chromatographic run. Intra- and interassay variability are