Chemie der Pleuromutiline, 11. Mitt.: Konfigurationsumkehr der Vinylgruppe am Kohlenstoff 12 durch reversible Retro-En-Spaltung

摘要

The reaction of pleuromutilin-22-0-tosylat(2) withEtZnI afforded a mixture of the 12-epimeric compounds2and3. A reversible retro-en-reaction of the homoallylic system is discussed as a possible mechanistic pathway. The structure assignment is based on1H- and13C-NMR spectroscopic data.