Organomagnesiate-Promoted Enantioselective Cascade Process: Straightforward Access to Chiral 3-Substituted Isobenzofuranones

摘要

abstract_textpThe bimetallic organomagnesiate ate complex (S)-(BIPHEN)BuMgLi is reported here as a dual efficient halogen-metal exchange and chirality transfer agent in the reaction of ethyl-2-iodobenzoate with aldehydes leading to the formation of various chiral 3-substituted isobenzofuranones in good yields and enantiomeric ratios./p/abstract_text