Cancer chemoprevention by 7-prenyloxycoumarins: a role for 5-lipoxygenase inhibition?

摘要

Cancer chemoprevention is defined as the use of synthetic, biological, chemical, or natural dietary components to inhibit, delay, or revert the development of cancer in normal or preneoplastic tissue. This strategy is regarded as one of the most encouraging areas in current cancer research. By way of characterization and development of effective and safe chemopreventive agents, natural products from plants and their synthetic derivatives have been extensively explored and are expected to play an important role in this field.