Major histocompatibility complex class II hyperexpression on B cells in interleukin 4‐transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia

摘要

AbstractThe murine interleukin 4 (IL 4)‐encoding cDNA expressed under the control of the immunoglobulin heavy chain enhancer/promoter was inserted into the mouse germ line. All B cells present in the IL 4 transgenic mice show a marked increase in expression of class II histocompatibility (Ia) antigens compared to B cells from control mice.In vivo5‐bromo‐2′‐deoxyuridine incorporation and cell cycle analysis revealed no significant increase in B cell proliferation in spleens of IL 4 transgenic mice compared to littermate controls. Likewise, serum immunoglobulin concentrations in IL4 transgenic mice were not increased. From these experiments we conclude that Ia hyperexpression on B cellsper sedoes not induce activation of autoreactive T cells leading to B cell proliferation or hypergammaglo