A facile and rapid one-pot synthesis of 1,4-diaryl-2-mercaptoimidazoles under solvent-free conditions

摘要

A highly efficient and green synthesis of l,4-diaryl-2-mercaptoimidazoles 4 is described.Potassium carbonate catalysed reaction of alpha-tosyloxyacetophenones 1 with various anilines 2 afforded alpha-anilinoacetophenones 3,which in situ underwent cyclization with potassium thiocyanate and p-toluenesulphonic acid in solvent-free conditions to yield 1,4-diaryl-2-mercaptoimidazoles 4 inexcel-lent yield.This one-pot protocol offers a useful modification as it has advantages of short reaction times,cleaner reaction profiles and simple work-up that exclude use of toxic solvents.