A case of asymmetric moderately increased fluorodeoxyglucose (FDG) uptake into muscle is shown. A 57-year-old right-handed man with non-Hodgkin lymphoma underwent a FDG positron emission tomographic (PET) scan to assess response to chemotherapy. Two days before the PET scan, the patient had spent several hours digging in his garden. He was relatively inactive during the 48 hours before the PET study. Marked skeletal FDG uptake is generally reported in subjects who have exercised before or after the injection of FDG. The authors present a case of increased muscle FDG uptake 48 hours after cessation of strenuous muscle activity.
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