The NA-XTD~(TM) Influenza Neuraminidase Assay Kit: extended-glow chemiluminescence assay system for highly sensitive influenza neuraminidase assays

摘要

The Applied Biosystems~R NA-XTD~(TM) Influenza Neuraminidase Assay Kit provides the next-generation NA-XTD~(TM) 1,2-dioxetane chemiluminescent neuraminidase (NA) substrate, together with all necessary assay reagents and micro-plates, to quantitate sensitivity of influenza virus isolates to neuraminidase inhibitors. Like the NA-Sfar~R Influenza Neuraminidase Inhibitor Resistance Detection Kit, the NA-XTD? Influenza Neuraminidase Assay provides highly sensitive detection of influenza neuraminidase activity. In addition, the NA-XTD? assay provides extended-glow light emission that eliminates the need for reagent injection and enables signal measurement either immediately or up to several hours after assay completion. The NA-XTD~(TM) assay is also used to quantitate influenza NA activity directly in cell-based virus cultures to monitor viral growth or inhibition.Global monitoring of influenza strains for resistance to neuraminidase inhibitors (NIs) is essential for understanding their efficacy for seasonal, pandemic, or -avian influenza, and studying the epidemiology of viral strains and resistance mutations. Functional neuraminidase inhibition assays enable detection of any resistance mutation, making them extremely important for global monitoring of virus sensitivity to NIs.