Is serotonin a valuable parameter in peripheral arterial disease?

摘要

Objective: In this study, we aimed to evaluate the relationship of serum serotonin levels, which are supposed to affect vascular function, to peripheral arterial disease. Methods: This prospective study was performed in 70 patients (57 males, 13 females; mean age 67±13 years) with peripheral arterial disease scheduled for surgery and 70 controls (52 males, 18 females; mean age 58±12 years). Results: The rates of diabetes mellitus and hypertension and the fasting glucose levels were significantly higher in the peripheral arterial disease group (p=0.001). Total, low-density, and high-density cholesterol, triglycerides, urea, and creatinine levels, and the smoking rate were similar in both groups (p>0.05). The serotonin levels were significantly higher in patients with peripheral vascular disease scheduled for surgery compared to the control group (p=0.024). Conclusion: The plasma serotonin level is an important parameter in peripheral arterial disease.