A study on the doubleMannichreaction with 1,3-diphenylacetone

摘要

DoubleMannichreaction of the title compound1with morpholine acetate in ethanol gave the symmetrical bis-base2, whereas such reaction in acetic acid afforded the vinyl-ketonic base3. Reactions of3with morpholine, piperidine, thiophenol and dimethyl phosphite were investigated.Mannichreaction of2with primary amines gave di-basically substituted γ-piperidones6a-b. Compound1reacts with ethylenediamine and formaldehyde to give the diazatricyclic system7