Topical use of tranexamic acid

摘要

I read with interest the article by Aoki and colleagues. In their study that included 100 consecutive patients who underwent off-pump coronary artery bypass between July 2009 and January 2011, 50 patients in the early phase group (N) did not have tranexamic acid, and 50 in the late phase (group T) were given tranexamic acid. They found that local administration of tranexamic acid decreased the volume of postoperative blood loss by approximately 40%. We published our results of local administration of tranexamic acid in patients undergoing coronary artery bypass and randomized to receive local tranexamic acid or placebo. We found that use of local tranexamic acid reduced postoperative drainage with no difference in red blood cell transfusion. I would like to congratulate the authors for their excellent study, and I have some remarks.