Genetic analysis workshop III: Sib pair analyses to determine linkage groups and to order loci

摘要

AbstractThe methods proposed by Haseman and Elston 1972 were used to estimate the proportion of genes identical by descent shared by each sib pair at each locus. These estimates were then used as a basis for obtaining all possible locus‐locus correlations. The 12 significant correlations (P<.01) and their rank order indicated the correct linkage groups and the order of the loc