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外文期刊>european journal of immunology
>T‐T cell interactions duringin vitrocytotoxic T lymphocyte responses. III. Antigen‐specific T helper cells release nonspecific mediator(s) able to help induction of H‐2‐restricted cytotoxic T lymphocyte responses across cell‐impermeable membranes
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T‐T cell interactions duringin vitrocytotoxic T lymphocyte responses. III. Antigen‐specific T helper cells release nonspecific mediator(s) able to help induction of H‐2‐restricted cytotoxic T lymphocyte responses across cell‐impermeable membranes
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机译:T‐T cell interactions duringin vitrocytotoxic T lymphocyte responses. III. Antigen‐specific T helper cells release nonspecific mediator(s) able to help induction of H‐2‐restricted cytotoxic T lymphocyte responses across cell‐impermeable membranes
AbstractT helper cell induction and the specificity of T cell‐mediated help as generated during alloreactive and H‐2‐restricted, virus‐ or hapten‐specific cytotoxic T lymphocyte (CTL) responses have been compared. With the use of a double‐chamber culture system, it was possible to dissect and separately analyze the induction phase of T helper cells from the T helper cell effector function. The data obtained revealed that during alloreactive as well as H‐2‐restricted T cell responses, antigen‐specific T helper cells are induced. Upon specific restimulation of T helper cells, helper cell function is mediated across a cell‐impermeable membrane via soluble products in an apparently nonspecific and nonrestricted manner. The data suggest that similar rules govern T‐T cell interactions in alloreactive and H‐2
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