Improved synthesis of nitriles of quinolone antibiotics

摘要

The parasites that cause malaria (Plasmodium vivax,Plasmodium falciparum,and Plas-modium malariae) are becoming resistant to current treatment methods.In the course of our studies toward the preparation of tetrazole derivatives of commercially available antibiotics for potential application in the treatment of malaria,we required the corresponding nitrile derivatives.