Reactivity of 4-bromomethylquinoline derivatives towards glycine and thioglycolic acid. A new ring system

摘要

Condensation of 4-bromomethylquinoline derivatives1 a-1 cwith glycine and thioglycolic acid gave the corresponding quinolylmethylglycine and quinolylmethylthioacetic acid derivatives2 a-2 cand2 d-2 f, respectively. Cyclization of2 a-2 fwas affected either by polyphosphoric acid or concentrated sulphuric acid to give3 a-3 f. Chlorination of2 a-2 fand3 a-3 fwere also accomplished.