Background: Although surgery is an effective treatment for severe carpal tunnel syndrome (CTS), it is accompanied by many complications; furthermore, there are several patients with severe CTS who reject surgical management. This study was designed to investigate the efficacy of long-term splinting in severe CTS. Methods and Materials: CTS Assessment Questionnaire (Bostone) was filled for 140 patients with severe CTS, who did not agree to go under surgery. Patients were divided into two groups randomly. One group received medical and physical therapy and short-term (six weeks) wrist splint. The other group received the same treatments but long-term (six months) splinting. Both groups went under the evaluation of symptoms and function with Bostone questionnaire and electrophysiological study six weeks, and six months later.
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