New gold(I) and silver(I) complexes of sulfamethoxazole:Synthesis,X-ray structural characterization and microbiological activities of triphenylphosphine(sulfamethoxazolato-N2)gold(I) and (sulfamethoxazolato) silver(I)

摘要

Sulfamethoxazole (SMTZ) reacts with Ph3PAuCl and AgCl in methanol/triethylamine to give [Ph3PAu(SMTZ_(-1H+))] (SMTZ_(-1H+)=sulfamethoxazolato anion) (1) and [Ag(SMTZ_(_1H+))] (2).While the lattice of 1 contains single molecules with linear N-Au-P bonds,compound 2 comprises a two-dimensional polymeric assembly of the deprotonated SMTZ ligand and silver ions,which are coordinated by one oxygen and three nitrogens in a distorted tetrahedral array.The microbiologic activities (Mueller-Hinton broth dilution tests) of 1 and 2 were determined in relation to free sulfamethoxazole.