pNA binding behaviors and nuclease activities of novel mixed-ligand ruthenium(II) complexes

摘要

Two types of ruthenium(II) complexes cis-[Ru(bpy)2CIL]~+ and cis-[Ru(bpy)2L2]~(2+) (L = 1,6-diaminohexane (1,6-dahx), 1-aminohexane (1-ahx)) were synthesized, and the interactions of these complexes with DNA were investigated. Importantly, cis-[Ru(bpy)2(1,6-dahx)2]~(2+) possessed hydrogen-bonding to DNA, preferentially binds at adenine and/or thymine residues, and exhibits more efficient nuclease activity.