Higher risk of primary cancers after polycythaemia vera and vice versa

摘要

To our knowledge, there are no population-based epidemio-logical data concerning whether individuals with polycythaemia vera (PV) are at an elevated risk of developing solid tumours and vice versa. This study aimed to systematically quantify the risk of all primary cancers after PV and vice versa for the first time.Since the mid-1950s, patients with haematological disorders in Sweden are primarily diagnosed, treated, and followed clinically by physicians at hospital-based haematology/oncol-ogy centres and each incident case of cancer is reported to the nationwide Swedish Cancer Registry. In Sweden, the criteria for PV diagnosis have changed from those of the Polycythaemia Vera Study Group (mid-1970s-late-1990s) to the World Health Organization criteria (Landgren et al, 2008).