Antibacterial activity, synthesis and characterisation of complexes of Cu~(II), Ni~(II), Zn~(II), Fe~(II), Mn~(II), Pd~(II) and Cd~(II) with thiosemicarbazone of 2-acetylbenzimidazole {(2E)-2-[1-(1H-benzimidazole-2-yl)ethylidiene]hydrazinecarbothioamide}

摘要

Thiosemicarbazone of 2-acetylbenzimidazole {(2E)-2-[1-(1H-benzimidazole-2-yl) ethylidiene] hydrazinecarbothioamide} (HActtsc) is strong (N, S) donor complexing molecules and form chelates with Co~(II), Ni~(II), Fe~(II), Cu~(II), Mn~(II), Zn~(II), Cd~(II) and Pd~(II) of composition M (Acttsc)2. nH2O (n = 0,1 or 2) in neutral or basic medium. In anhydrous ethanol or methanol Cu~(II), Ni~(II), Zn~(II), and Cd~(II) form dihalo complexes of composition [M(HActtsc)X2] (X = Cl or Br). The complexes have been analysed and characterised from the studies of electrical conductance value, magnetic susceptibility measurement, electronic absorption and infrared spectral data. The antibacterial activity of HActtsc and its complexes have been evaluated against some gram positive and gram negative bacteria by disc diffusion method.