Familial Mediterranean Fever Gene (MEVF) Mutations in Crohn's disease in a Mediterranean Area

摘要

Familial Mediterranean fever (FMF) is an inflammatory disorder characterized by an uncontrolled immune response. The disease is prevalent in the Mediterranean area and the MEVF gene, responsible for FMF, has been localized on chromosome 16pl3 and encodes for pyrin, which has been implicated in the regulation of neutrophil activity.1 Recently, Fidder et al2 evaluated the association of MEVF mutations with CD and did not find a significant association with CD susceptibility but suggested that carrying of MEVF mutations may have an impact on the clinical manifestation of CD.