Culture-Negative Endocarditis and the Use of Molecular Diagnostics A Case Report

摘要

The management of infective endocarditis (IE) is very challenging in patients with blood cultures negative for a microorganism. Unfortunately, this situation is not uncommon, occurring in up to 30% of cases of IE. Precise microbiological diagnosis, however, is critical to optimize the antibiotic regimen, and thus, non-culture-based molecular techniques are playing a growing role in the care of these patients. We present a patient with culture-negative IE due to Hae-mophilus parainfluenzae, with the pathogen identified only via molecular techniques.