Abstract.The purpose of the present study was to examine the composition of the oral microbiota in subjects who had previously demonstrated to develop either a weak or strong response to experimental gingivitis. For this study, subjects were selected from a pool of 25 individuals who had participated twice in an experimental gingivitis trial. Out of these 25 panellists, 6 subjects were selected who had developed 2× a weak gingival inflammatory response and 7 subjects who had developed 2× a strong gingival inflammatory response. Approximately 9 months after the 2nd experimental gingivitis trial, we evaluated the clinical condition and the prevalence of a panel of selected oral micro‐organisms in these subjects. The subjects were clinically examined for the presence of plaque, bleeding, pocket depth and loss of attachment. For the microbiological evaluation, samples were taken from the mucous membranes, subgingival sites and saliva. Samples were analyzed for the presence ofActiilobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Peptostreptococcus micros. Actinomycesspp.,Fusohacterium mucleatum, Campylobacter rectus, spirochaetes and motile rods. Clinical evaluation showed that most subjects had a relatively healthy periodontal condition. No clinically significant differences could be detected between the weak and strong responding groups. The microbial evaluation showed absence ofA. actinomycetemcomitans, P. gingivalisandP. microsin all subjects in either group. Analysis of the microbial data for the weak and strong responding group showed no differences between the groups. This indicates that differences in response to experimental gingivitis are probably not caused by major differences in the compositon of the oral microbiota. The strong or weak inflammatory response may be related to differences in the microflora at the time of the experiments and/or differences in host respo
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