In silico multiple-targets identification for heme detoxification in the human malaria parasite Plasmodium falciparum

摘要

Detoxification of hemoglobin byproducts or free heme is an essential step and considered potential targets for anti-malaria drug development However, most of anti-malaria drugs are no longer effective due to the emergence and spread of the drug resistant malaria parasites. Therefore, it is an urgent need to identify potential new targets and even for target combinations for effective malaria drug design.