Mutagenicity of hydrolyzed proteins

摘要

The presence of 3-chloro-1,2-propanediol (MCP) in hydrolyzed proteins (HPs) was reported, due to the reaction of excessive hydrochloric acid in the system with glycerine derived from neutral fat triglyceride. Since MCP induced immobility of rat sperm and showed mutagenicity against some bacterial test strains, its concentration should be kept as low as possible. Here we report the distribution of MCP in HPs commercially available during 1990-91. The mutagenicity of MCP in these HPs was below the detection limit of the microbiological assay system we employed. Owing to efforts made by manufacturers, no MCP is detectable in HPs currently manufactured in Japan. However, microbiological mutagenic studies indicated that weak, but significant, mutagenicity still exists in some HPs.