Differentiation of Ovine Immature B Cells upon Exposure to Phorbol Myristate Acetate

摘要

Immature B cells obtained from the ileal Peyer’s patches (IPPs) of sheep, upon exposure to phorbol myristate acetate (PMA), expressed 20–30 times more sIgM per cell than nonstimulated IPP cells, and the sIgM level was the same as that of peripheral B cells. The exposure of IPP cells to PMA also induced IgM secretion. Macrophages were not required for the terminal differentiation of IPP cells in vi