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Antidermatophytic activity of volatile oil and nanoemulsion of Stenachaenium megapotamicum (Spreng.) Baker.

机译:挥发油的抗皮肤真菌活性和大千金藤面包的纳米乳液。

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Volatile oils have important biological properties, like antifungal activity. Several studies have investigated the ability of nanoparticulate systems as carriers of these substances in order to stabilize and reduce their volatility and improve their effects. The aims of this study were to analyze the chemical composition of volatile oil of Stenachaenium megapotamicum and to evaluate the antifungal activity of the pure oil and its nanoemulsion. The volatile oil obtained by hydrodistillation was analyzed by gas chromatography coupled to mass spectrometry and presented 52.6% of sesquiterpenes. Fokienol was the most abundant compound (24.4%), followed by 7-(isopentyloxy)-2H-chromen-2-one (17.9%), thymol (10.8%) and beta -bisabolene (9%). The nanoemulsion was obtained by spontaneous emulsification and exhibited translucent appearance, pH 5.14, particle diameter of 210 nm and polydispersity of 0.369. Apart from volatile oil and nanoemulsion, thymol also was tested for antifungal activity. The volatile oil and thymol exhibited antidermatophytic activity, presenting selectivity against the filamentous fungi Epidermophyton floccosum, Scytalidium dimidiatum and Trichophyton rubrum. Significantly reduced minimal inhibitory concentration and minimal fungicidal concentration were observed for the nanoemulsion containing volatile oil of S. megapotamicum, when compared with the activity of pure oil and of thymol, demonstrating the ability of the nanoparticulate system to improve oil activity.
机译:挥发油具有重要的生物学特性,例如抗真菌活性。几项研究已经研究了纳米颗粒体系作为这些物质的载体的能力,以稳定和减少其挥发性并改善其效果。这项研究的目的是分析巨大的Stenachaenium megapotamicum挥发油的化学成分,并评估纯油及其纳米乳液的抗真菌活性。通过加氢蒸馏得到的挥发油通过气相色谱-质谱联用分析,得到52.6%的倍半萜烯。福基诺尔是​​含量最高的化合物(24.4%),其次是7-(异戊氧基)-2H-铬-2--2-酮(17.9%),百里酚(10.8%)和β-双丁烯二烯(9%)。通过自发乳化获得纳米乳液,并显示出半透明的外观,pH 5.14,粒径为210nm,多分散度为0.369。除挥发油和纳米乳剂外,还对百里酚进行了抗真菌活性测试。挥发油和百里香酚具有抗皮肤癣菌的活性,对丝状真菌表皮絮状菌,旋毛虫和红毛癣菌具有选择性。当与纯油和百里香酚的活性相比时,观察到含有大麦链球菌挥发油的纳米乳剂的最小抑菌浓度和最小杀真菌剂浓度显着降低,证明了纳米颗粒体系改善油活性的能力。

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