A new biodegradable polymeric nanoparticle formulation containing Syzygium cumini: Phytochemical profile, antioxidant and antifungal activity and in vivo toxicity

摘要

Syzygium cumini seeds were used for the preparation of an aqueous extract (ASc) and of polymeric nanoparticles containing ASc (NPASc) with the aim to evaluate and compare their in vitro efficacy against the complications of Diabetes mellitus (DM) and the in vivo toxicity. NPASc were produced by the emulsification/evaporation solvent technique, employing poly-epsilon-caprolactone, a biocompatible polymer. The antioxidant activity of both ASc and NPASc was evaluated by the scavenging of DPPH radicals and by the ferric reducing antioxidant power assay (FRAP). The in vitro efficacy of both formulations against oxidized LDL particles (ox-LDL) and fungal species was also assessed.