Mathematical modeling of fed-batch butanol fermentation with simultaneous pervaporation

摘要

A mathematical model was developed to describe a fed-batch acetone-butanol-ethanol (ABE) fermentation with simultaneous pervaporation. The model predicted satisfactorily batch or fed-batch fermentation with or without pervaporalion by introducing a parameter reflecting cell activity loss during fed-batch fermentation with pervaporation. The model also predicted the effect of membrane area, membrane thickness, and sweep air flow rate on glucose consumption rate and residual butanol concentration in the fermentation broth. Glucose consumption rate increased by 30 by either doubling the membrane area or decreasing membrane thickness by half.