The Effects of 2comma;5hyphen;Hexane Dione on Remyelination in the Peripheral Nervous System of the Mouse

摘要

We compared the development and resolution of a demyelinating lesion (produced by the intraneural injection of lysophosphatidyl choline) in mice exposed to a known neurotoxic agent (2, 5-hexane dione) with similar events in control animals. A prolongation of the pro-myelin stage was observed in the hexane dione-treated animals: the suppression of remyelination became progressively more marked with the length of exposure to hexane dione. Prolongation of the pro-myelin stage is an indication of a disturbance in some component of the complex interaction between Schwann cell and axon, and presumably reflects the neurotoxicity of 2, 5-hexane dione.