Effects of Human Recombinant Erythropoietin on Anaemia, Systemic Haemodynamics and Renal Function in Predialysis Renal Failure Patients

摘要

Seven anaemic patients with predialysis chronic renal failure were treated with human recombinant erythropoietin. Anaemia was improved, with a 31increase in haematocrit, but blood pressure increased in all patients with an average of 12in systolic (P<0.01), 14in diastolic (P<0.05) and 13in mean blood pressure (P<0.05). Blood volume was significantly increased by an average of 12. Cardiac output increased in three of seven patients, and total peripheral resistance in four. GFR, RBF and RPF were not changed but filtration fraction increased significantly (P<0.05). It is suggested that blood pressure elevation might be developed as a result of volume expansion, elevated cardiac output, and increased total peripheral resistance.