Colony Formation by Subpopulations of Human T Lymphocytes

摘要

Phytohaemagglutinin‐induced human T‐lymphocyte colony formation in semisolid agar culture is the properly of erythrocyte rosette‐forming cells (E‐RFC) negative for the 7S IgG receptor (FcR−). E‐RFC positive for the 7S IgG receptor (FcR+), on the other hand, exhibit a limited capacity for colony formation and suppress colonies formed by FcR−E‐RFC. T colonies are composed of small lymphocytes and lymphoblasts, the vast majority being negative for the Fc receptor. Most colony cells (86) carry the Leu 3a antigen, suggesting that they belong to the inducer/helper T‐cell subset, FcR+colony suppressor cells are small, slowly sedimenting cells (sedimentation velocity<3.8 mm/h) and are strongly adherent to plastic, and their activity depends on the ability