A Research Immunobead- Assay for Flow Cytometric Detection of BCR-ABL Fusion Proteins

摘要

The Philadelphia chromosome, the BCR-ABL translocation t(9;22) (q34;q11) in blood stem cells, results in the fusion of the BCR and ABL (BCR-ABL) genes, which leads to the expression of the constitutively active tyrosine kinase BCR-ABL fusion protein.The Philadelphia chromosome is the hallmark of chronic myeloid leukemia (CML) and is present in a poor-risk subset of precursor B cell acute lymphoblastic leukemia (ALL). A rapid, accurate technique for detecting the abnormal BCR-ABL fusion protein would be extremely useful in future studies involving the biology of these diseases.