A pathogenetic model for erosive synovitis. Lessons from animal arthritides

摘要

AbstractAdjuvant arthritis, streptococcal cell wall—induced arthritis, andErysipelothrix insidiosaarthritis are laboratory models of relapsing, erosive synovitis. A review of the experimental literature suggests that their pathogenesis is similar. The persistence in macrophages in the pannus of nonbiodegradable microbial cell wall components containing the peptidoglycan moeity is the central event. Based on this experimental literature, a model for the pathogenesis of these arthritides is developed. This model is testable and relevant to erosive synovitis in ma