The Role of Umbilical Cord Blood Insulin Like Growth Factor-1 Levels in the Assessment of Bone Maturation in Term Neonates

摘要

Purpose: In this study, we aimed to investigate the relation of anthropometric data and knee epiphyseal area with cord blood Insulin Like Growth Factor-1 (IGF-1) levels at birth in term neonates. Material and Method: Twenty-six term neonates were recruited. Anthropometric measures and the knee epiphyseal area were recorded and umbilical cord blood samples were collected at birth. The knee epiphyseal area was calculated by the addition of width x height x 3.1415/4 of the distal femoral epiphysis and proximal tibia epiphysis. Results: Mean concentrations of IGF-1 levels of cord blood and the knee epiphyseal area were 45.2 +/- 36.8 ng/ml and 29.0 +/- 18.4 mm2 in term neonates, respectively. IGF-1 levels correlated significantly with knee epiphyseal area (r: 0.45, p: 0.018). In a multiple regression model, IGF-1 emerged as independent correlates for mean knee epiphyseal area in term neonates with the total variance being 18 Although IGF-1 level had significantly positive correlations with body surface area, birth weight, midarm circumference did not correlate with gestational age, birth length, head circumference, ponderal index and skinfold thickness. Conclusion: Cord blood IGF-1 level is useful for assessing the bone maturation in neonates, bccausc a changes in IGF-1 correlates with the change in cpiphyscal area.