AUTONOMIC FAILURE WITH ORTHOSTATIC HYPOTENSION DUE TO INTERMEDIOLATERAL COLUMN DEGENERATION

摘要

Two patients who had autonomio failure with orthostatic hypotension are described. Physiological studies indicated a preganghonic sympathetic lesion in the central nervous system.Post-mortem examination in both cases showed severe nerve-cell loss in the intermediolateral columns (preganghonic sympathetic cells) of the spinal cord.One case also showed the lesions of olivo-ponto-cerebellar atrophy. Both patients are considered to have been suffering from a primary neuronal degeneration.