Microscale parallel synthesis of indoles and amides using robotics and solution-phase chemistry

摘要

Microscale parallel synthesis using solutionphase chemistry is automation intensive compared to solid-phase chemistry. Although many researchers believe that solid-phase chemistry is still the best solution for combinational chemistry, recent reports by Kaldor and coworkers at Eli Lilly & Co. (Indianapolis, IN) on the solution-phase covalent scavenger technology indicate that the reaction product can be formed by solution-phase synthesis, and the unreacted starting material can then be removed using a solid-phase support.