A nanoflow electrospray method for DNA-adduct analysis

摘要

Deoxyribonucleic acid (DNA) is the genetic blueprint for all known life and serves as the template for the production of structural and regulatory proteins. DNA has a double-helix structure, with each helix consisting of a linear polymeric chain that incorporates alternating phosphate groups and deoxyribose sugar units. In addition, each sugar is attached to one of four possible organic nitrogen bases: guanine, cytosine, adenine, and thymine. These bases hydrogenbond to a partner base (cytosine to guanine, and adenine to thymine) at the center of the double helix and thus maintain the structural integrity of the molecule.