Synthesis of pyridine derivatives by reactions of α,β-unsaturated nitriles with 2-oxo-cycloalkano carbothioic acid anilides

摘要

The tandem Michael addition-cyclization of 2-oxo-cycloalkane carbothioic acid anilides1–3to benzylidenemalononitrile4yielded spiroannulated pyridines5–7. Reaction of acrylonitrile with2and3gave 2,2-disubstituted Michael adducts14,15, whereas with1led to 2,2,5-tri(2-cyanoethyl)-cyclopentanon