Studies on diagnostic and therapeutic options in dogs suffering from benign prostatic hyperplasia

摘要

The study was conducted on 10 dogs presented with prostate involvement with an aim to determine effective diagnostic and therapeutic options for managing benign prostatic hyperplasia (BPH). The disease was more common in middle to old aged dogs. Urinalysis revealed normal or concurrent urinary tract infection. Elevated activity of serum alkaline phosphatase was seen. Culture of prostatic fluid revealed no bacterial growth. Objective radiographic and ultrasonographic assessment was found superior to conventional subjective assessment. Ultrasound-guided fine-needle aspiration biopsy using free hand technique obtained good quality prostatic tissue sample for confirmatory diagnosis. The BPH cases were grouped under 3 groups that received either Finasteride (@ 5mg total dose for 6 weeks), Dutasteride (@ 0.5 mg total dose for 6 weeks) or underwent castration. Treatment with finasteride, dutasteride or castration produced similar and comparable results in the form of prostatic volume reduction and alleviation of clinical signs. Both drugs did not produce any deleterious effect on vital organ functions and were found safe in dogs.